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STRING Database MCP Server

作者:meringlab版本 1.13.1i★ –i在云端运行
注册名称org.string-db/string-mcp

安装

概览

作者提供的说明(英文原文)

Query STRING interactions, enrichment, annotations, homology, and PPI networks.

PopNx MCP 的三大支柱

这三项永远不会合并成一个分数:意见、测量和人气是不同的东西。

它能帮你做什么

我们还没有为它写通俗的介绍。下面是我们从注册中心读取到的事实。

  • 连接方式: 在云端运行
  • 传输方式: Streamable HTTP
  • 分类: 数据库与数据集

安装

选择你使用的 AI 应用,然后复制设置。

安装之前

你需要

你用的是哪个应用?

在上方选择你的应用。我们会记住它,下次按钮会显示“安装到 …”。

适用于网页版、桌面版和手机版 Claude:

  1. 打开 Settings → Connectors
  2. 点击 Add custom connector
  3. 粘贴下面的地址,然后点击 Add
  4. 如果要求登录,请登录作者的服务
SettingsConnectors1+ Add2https://…3
https://mcp.string-db.org/

在终端中运行这条命令

claude mcp add --transport http string https://mcp.string-db.org/

在 Cursor 中打开

或者自己复制设置

粘贴到项目中的 .cursor/mcp.json,或 ~/.cursor/mcp.json

{
  "mcpServers": {
    "string": {
      "url": "https://mcp.string-db.org/"
    }
  }
}

浏览器会先询问是否打开应用,然后应用会显示设置并请你确认。密钥的值会留空,由你自己填写。

在 VS Code 中打开

或者自己复制设置

粘贴到项目中的 .vscode/mcp.json

{
  "servers": {
    "string": {
      "type": "http",
      "url": "https://mcp.string-db.org/"
    }
  }
}

浏览器会先询问是否打开应用,然后应用会显示设置并请你确认。密钥的值会留空,由你自己填写。

ChatGPT 只能连接互联网上的服务器:

  1. 打开网页版 ChatGPT → Settings → Connectors (Apps)
  2. 点击 Create 或 Add(部分套餐需要先在 Advanced 中开启 Developer mode)
  3. 粘贴下面的地址,起个名字,然后保存
  4. 如果要求登录,请登录作者的服务
SettingsConnectors1+ Create2https://…3
https://mcp.string-db.org/

菜单名称可能因套餐和版本不同而略有差异。

你的选择通过 Cookie 保存在这台设备上,无需账户。

这些设置是根据作者在注册中心的条目生成的。如果 README 的写法不同,请以 README 为准。

它能做什么

工具名称和描述与服务器在 2026年11月7日 报告的完全一致。这些内容由作者撰写,不是我们写的;我们以纯文本形式显示。

  • string_resolve_proteins

    Maps one or more protein identifiers to their corresponding STRING metadata, including: gene symbol, description, sequence, domains, species, and internal STRING ID. This method is useful for translating raw identifiers into readable, annotated protein entries. Example input: "TP

  • string_interactions_query_set

    Retrieves the interactions between the query proteins. Use this method only when you specifically need to list the interactions between all proteins in your query set. - For a **single protein**, the network includes that protein and its top 10 most likely interaction partners, p

  • string_all_interaction_partners

    Retrieves all interaction partners for one or more proteins from STRING. This tool returns all known interactions between your query protein(s) and **any other proteins in the STRING database**. - Use this when asking **“What does TP53 interact with?”** - It differs from `string_

  • string_visual_network

    Retrieves a URL to a **STRING interaction network image** for one or more proteins. - For a single protein: includes the protein and its top 10 most likely interactors. - For multiple proteins: includes all known interactions **within the query set**. The input may include one nu

  • string_network_clustering

    Performs **network clustering** on a STRING interaction network and returns a network image URL, an interactive STRING network URL, and details about each detected cluster. Provide a table with each detected cluster’s color, STRING-derived functional description, and any returned

  • string_network_link

    Retrieves a stable URL to an interactive STRING network for one or more proteins. - For a single protein: includes the protein and its top 10 most likely interactors. - For multiple proteins: includes all known interactions **within the query set**. The input may include one nume

  • string_homology

    Retrieves pairwise protein similarity scores (Smith–Waterman bit scores) for the query proteins. - If no target species (`species_b`) is provided, results are intra-species (within the query species). - To retrieve homologs in other species or clades (e.g. vertebrates, yeast, pla

  • string_interaction_evidence

    Retrieves direct links to STRING evidence pages for protein–protein interaction pairs. Use this tool only when a STRING evidence page/link is needed. To determine whether an interaction is supported, use `string_interactions_query_set`. It returns URLs linking to STRING’s evidenc

  • string_enrichment

    This tool retrieves functional enrichment for a set of proteins using STRING. - If queried with a single protein, the tool expands the query to include the protein’s 10 most likely interactors; enrichment is performed on this set, not the original single protein. - For two or mor

  • string_functional_annotation

    This tool retrieves curated functional annotations for a set of proteins. Each input protein is mapped to known biological terms from ontologies, pathway databases, tissues, compartments and domains — such as Gene Ontology (GO), KEGG, and UniProt Keywords. - Use this when the use

  • string_enrichment_image_url

    Retrieves a STRING enrichment figure (image URL) for a set of proteins. For the enriched terms and FDR values, use `string_enrichment`. - Each figure shows a single enrichment category; call again with another `category` to show a different one. - Use the same proteins and specie

  • string_ppi_enrichment

    This tool tests if your network is enriched in protein-protein interactions compared to the background proteome-wide distribution (i.e., if your proteins are more functionally connected than expected by chance). - The enrichment is assessed using the actual observed edges versus

  • string_proteins_for_term

    Retrieve proteins annotated with a functional term or descriptive text in a single species. You can query for tissues, compartments, diseases, processes, pathways, and domains. IMPORTANT: For cross-species comparisons, run this tool separately for each species. Select relevant mo

  • string_sequence_search

    Searches the STRING database using **amino acid sequences** to identify matching proteins. - Accepts a single sequence or multiple sequences in FASTA format. - Returns the most similar STRING protein(s) for the specified species, based on sequence similarity. - Use this when the

  • string_query_species

    Search for species or clades available in STRING by free-text query and return their NCBI taxonomy IDs. - Use this when the user asks which species or clades are present in STRING, or when you need the correct NCBI taxon ID to pass to other tools. - use this to resolve NCBI taxon

  • string_create_file

    Creates a downloadable file for STRING-derived results. Use this tool when the user explicitly asks to download, save, export, or receive a file containing STRING data, tables, protein lists, enrichment results, networks, etc. When a response would otherwise include a publication

  • string_help

    Provides explanatory text for STRING features and limitations. Use this tool when the user question involves: - What is STRING is or how to use the tool (how_to_use_string, cytoscape) - functionality not available via MCP tools (e.g. GSEA or large datasets). - meaning of network

基础检查i

我们检查的是任何人都能看到的信息;我们没有阅读代码。不适用的检查项不计入总数。 · 检查于 2026年11月7日

  • ! 注意

    作者与仓库一致

    发布者(string-db.org)不是仓库所有者(meringlab);可能是其他人代为上架的

  • … 尚未检查

    仍在维护

    我们还没有从 GitHub 读取这个仓库

  • … 尚未检查

    有许可证

    我们还没有从 GitHub 读取这个仓库

  • ✓ 通过

    端点有响应

    在 862 毫秒内响应(HTTP 200)

  • – 不适用

    使用 OAuth 登录

    无需登录

  • ✓ 通过

    工具描述中没有隐藏指令

    已读取 17 个工具描述,未发现针对 AI 的隐藏指令

与“数据库与数据集”中的其他服务器比较i

  • 星标数多于此分类中其他 954 个服务器的 0%
  • 发布到注册中心的时间比此分类中其他 954 个服务器的 80% 更新
  • 基础检查结果等于或优于此分类中其他 954 个服务器的 42%

与注册中心里这个分类中所有活跃的服务器比较。只有当发布者拥有该仓库时,星标数才计入。

常见问题

STRING Database MCP Server 安全吗?

它在 3 项适用的基础检查中通过了 2 项。我们没有阅读代码。在添加密钥或令牌之前,请先看看这个服务器要求哪些权限,并使用只具备所需权限的密钥。

它需要哪些密钥或代码?

注册中心没有列出必需的密钥,不过有些服务器会在首次使用时要求你登录。

它在我的电脑上运行还是在云端?

它在作者的云端运行。通过互联网连接,无需安装,但你发送的内容会经过作者的服务器。

它还在维护吗?

GitHub 仓库最后更新于–,最新版本(1.13.1)于10天前进入注册中心。

哪些应用可以使用它?

支持 MCP 的应用,例如 Claude Desktop、Claude Code、Cursor 和 VS Code。它通过 URL 连接,所以接受远程 MCP 服务器的应用也可以使用,例如开启开发者模式的 ChatGPT。

有什么可以替代它?

同一分类中有:Supabase, MongoDB MCP Server, Elasticsearch MCP Server

替代选择

同一分类中其他作者的服务器,按星标数排序。

如何看卡片:★ GitHub 星标i三大支柱:评价 · 检查 · 使用情况i更新 = 最新版本发布到注册中心的时间i

Supabase

作者:supabase

MCP server for interacting with the Supabase platform

电脑或云端★ 2,993Apache-2.0今天更新
安装

MongoDB MCP Server

作者:mongodb-js

MongoDB Model Context Protocol Server

在你的电脑上运行★ 1,157Apache-2.0前天更新
安装

MCP server for interacting with Elasticsearch

在你的电脑上运行★ 315Apache-2.014个月前更新
安装

作者的 README

打开 README

按原文从作者的仓库复制。PopNx MCP 没有审查或背书其内容。HTML、图片和脚本已被移除。链接会离开本站。

Official STRING Database MCP Server

Exposes STRING database functionality as a Model Context Protocol (MCP) server.

This implementation allows AI agents and other MCP-compatible clients to access STRING data through a structured and self-describing interface.

It is built on top of the STRING API but adapted specifically for model-based use, with emphasis on conciseness and context efficiency. The server controls the amount and type of data so that responses stay within the reasoning limits of large language models. It also adapts the structure and adds metadata to support more consistent parsing and interpretation by agentic systems.

The server is also available as a hosted remote MCP endpoint at https://mcp.string-db.org.

For a live demonstration of MCP capabilities, see STRING Chat.

For reproducible workflows and large-scale integration, use the STRING API.

For agentic workflows, use the optional agent skill at skills/string-database/SKILL.md.

Features

  • Resolve protein identifiers to STRING metadata
  • Retrieve interaction networks
  • Cluster and visualize interaction networks
  • Perform homology lookups across species
  • Access evidence links for protein–protein interactions
  • Run functional enrichment analysis (including enrichment plots)
  • Get curated functional annotations for proteins
  • Query proteins by function or disease (GO, KEGG, Reactome, DISEASES etc.)

Requirements

  • Python ≥ 3.11 (with Python 3.10, optional parameter descriptions are misplaced in the tool schemas)
  • Dependencies (see requirements.txt):
  • fastmcp==2.14.7
  • mcp==1.29.0
  • httpx>=0.28,<0.29
  • pydantic>=2.11,<3.0

Note: If the server crashes on startup, it is very likely due to an incompatible FastMCP version.


Configuration

The server reads settings from config/server.config (JSON). Example:

{

"base_url": "https://string-db.org", "server_port": 57416, "verbosity": "low" }

Installation

git clone https://github.com/meringlab/string-mcp.git

cd string-mcp pip install -r requirements.txt

Running

python server.py

To serve over standard input/output instead of HTTP, for example when a local MCP client starts the server itself:

python server.py --stdio

The stdio mode also reads config/server.config for the STRING API endpoint.

Testing

   curl -v -H "Accept: text/event-stream" http://localhost:[port]/mcp

You should see a 200 OK response with content-type: text/event-stream.

Note: HTTP requests sent with default headers will trigger anyio.ClosedResourceError and 406 Not Acceptable. This is expected behavior for the MCP streaming protocol and does not indicate a problem.

Docker

  1. Ensure you have a config/server.config file (copy from config/server.config.example if needed):
   cp config/server.config.example config/server.config
  1. Build the image:
   docker build -t string-mcp .
  1. Run the container:

Linux/macOS:

   docker run -p 57416:57416 -v $(pwd)/config:/app/config:ro string-mcp

Windows PowerShell:

   docker run -p 57416:57416 -v ${PWD}/config:/app/config:ro string-mcp

Windows Command Prompt:

   docker run -p 57416:57416 -v %cd%/config:/app/config:ro string-mcp

To run in detached mode:

   # Linux/macOS

docker run -d -p 57416:57416 -v $(pwd)/config:/app/config:ro --name string-mcp-server string-mcp

Windows PowerShell

docker run -d -p 57416:57416 -v ${PWD}/config:/app/config:ro --name string-mcp-server string-mcp

The -v flag mounts your local config directory so you can customize settings without rebuilding the image.

Note: If you don't need to modify the config, you can omit the volume mount and the container will use the default config from the image.

  1. Stop the container (if running in detached mode):
   docker stop string-mcp-server

docker rm string-mcp-server

Note: The Docker container will use the configuration from config/server.config. If this file doesn't exist, the container will copy from server.config.example on first run.

Frozen STRING releases are available under versioned paths: /12.0/ (STRING v12.0) and /12.5/ (STRING v12.5).

License / Citation

The STRING MCP server source code is released under the MIT License. Associated data and outputs are released under the CC BY 4.0 License. You are free to use, share, and modify the code with proper attribution.

If you use this code or data in your work, please also cite the latest STRING manuscript.

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