Folklore Clinical Variant Interpretation MCP

Name: Folklore Clinical Variant Interpretation MCP
Author: helena-bioinformatics

作者：helena-bioinformatics版本 2.0.0i★ –i在云端运行

注册名称io.github.helena-bioinformatics/folklore

安装

概览

作者提供的说明（英文原文）

Germline ACMG/AMP classification, genes, disease associations, literature and API-key case analysis.

PopNx MCP 的三大支柱

这三项永远不会合并成一个分数：意见、测量和人气是不同的东西。

用户评价i暂无评价评价功能将在后续阶段与账户功能一起开放
我们的基础检查i3 项中通过 3 项依据公开信息检查；尚未扫描代码
使用情况i尚未统计★ –

它能帮你做什么

我们还没有为它写通俗的介绍。下面是我们从注册中心读取到的事实。

连接方式: 在云端运行
传输方式: Streamable HTTP
分类: 其他

安装

选择你使用的 AI 应用，然后复制设置。

安装之前

基础检查：3 项中通过 3 项
在作者的服务器上运行：你向它提出的内容会经过他们的服务器。
可以做 11 件事（工具） classify_germline_variant, search_variant_literature, get_publication_details, search_literature_corpus …
注册中心没有列出需要填写的密钥。

你需要

在云端运行无需安装任何东西，通过互联网连接

你用的是哪个应用？

ClaudeClaude CodeCursorVS CodeChatGPT

在上方选择你的应用。我们会记住它，下次按钮会显示“安装到 …”。

适用于网页版、桌面版和手机版 Claude：

打开 Settings → Connectors
点击 Add custom connector
粘贴下面的地址，然后点击 Add
如果要求登录，请登录作者的服务

https://api.helena.bio/folklore/v1/mcp

在终端中运行这条命令

claude mcp add --transport http folklore https://api.helena.bio/folklore/v1/mcp

在 Cursor 中打开

或者自己复制设置

粘贴到项目中的 .cursor/mcp.json，或 ~/.cursor/mcp.json

{
  "mcpServers": {
    "folklore": {
      "url": "https://api.helena.bio/folklore/v1/mcp"
    }
  }
}

浏览器会先询问是否打开应用，然后应用会显示设置并请你确认。密钥的值会留空，由你自己填写。

在 VS Code 中打开

或者自己复制设置

粘贴到项目中的 .vscode/mcp.json

{
  "servers": {
    "folklore": {
      "type": "http",
      "url": "https://api.helena.bio/folklore/v1/mcp"
    }
  }
}

浏览器会先询问是否打开应用，然后应用会显示设置并请你确认。密钥的值会留空，由你自己填写。

ChatGPT 只能连接互联网上的服务器：

打开网页版 ChatGPT → Settings → Connectors (Apps)
点击 Create 或 Add（部分套餐需要先在 Advanced 中开启 Developer mode）
粘贴下面的地址，起个名字，然后保存
如果要求登录，请登录作者的服务

https://api.helena.bio/folklore/v1/mcp

菜单名称可能因套餐和版本不同而略有差异。

你的选择通过 Cookie 保存在这台设备上，无需账户。

这些设置是根据作者在注册中心的条目生成的。如果 README 的写法不同，请以 README 为准。

它能做什么

工具名称和描述与服务器在 2026年11月7日报告的完全一致。这些内容由作者撰写，不是我们写的；我们以纯文本形式显示。

classify_germline_variant
Classify one GRCh38 germline nuclear SNV or simple indel smaller than 50 bp under ACMG/AMP. Accepts genomic, coding or protein HGVS, coordinates, SPDI, rsID or a returned canonical key. Returns normalized identity, automated classification, applied criteria, ClinVar assertions, p
search_variant_literature
Resolve one GRCh38 germline variant and retrieve publications from the PubMed-derived genetics corpus. Exact variant mentions rank ahead of broader gene associations. Returns match types, source links, corpus provenance and retrieval time.
get_publication_details
Retrieve one PMID from the PubMed-derived genetics corpus, including title, abstract, authors, journal, publication types, MeSH terms, gene and variant mentions, retraction status and PubMed/PMC links.
search_literature_corpus
Search the genetics Literature Corpus by question, PMID, DOI, PMCID, gene, variant, phenotype, HPO or OMIM concept. Known publication identifiers provide exact anchors. Returns ranked publications, match types, scores and source links.
support_helena
Retrieve Helena Good campaign, rules, manifest and MCP connection URLs.
get_gene_disease_associations
Find diseases associated with an exact gene symbol or HGNC identifier. Returns ClinGen gene-disease validity assertions, relation-specific inheritance, source reports and snapshot provenance, including conflicting and limited assertions.
search_disease_genes
Find genes associated with an exact MONDO identifier or disease-name search. Returns ClinGen validity assertions with inheritance, source reports and snapshot provenance. Name searches can return multiple disease identities.
resolve_gene
Resolve a human gene symbol, previous symbol, alias, HGNC, Ensembl or NCBI Gene identifier. Returns exact, alias, ambiguous, not_found or withdrawn status with candidates and identity_snapshot_id. Use a selected HGNC gene_id and snapshot_id with get_gene_profile. Gene-plus-HGVS a
get_gene_profile
Read the selected gene_id and immutable snapshot_id from resolve_gene. Returns overview, disease validity, dosage, mechanisms, transcripts, native assemblies, constraint, ClinVar summaries and consequences, expression, GWAS, phenotypes and protein/pathways with source assertions,
get_gene_section
Read a gene-profile section using gene_id, snapshot_id and its returned opaque cursor. Returns source records, assembly/release, coverage, totals, count units and provenance. snapshot_unavailable requires a fresh resolution/profile request.
search_gene_literature
Retrieve a live publication capture for a resolved gene_id and snapshot_id. Returns source links, match labels, capture time/hash, degradation and gene/snapshot/sort-bound cursors. This capture is separate from the immutable reference snapshot and contains no abstracts.

基础检查i

我们检查的是任何人都能看到的信息；我们没有阅读代码。不适用的检查项不计入总数。 · 检查于 2026年11月7日

✓ 通过
作者与仓库一致
注册名称已通过 GitHub 账户 helena-bioinformatics 验证，该账户拥有此仓库
… 尚未检查
仍在维护
我们还没有从 GitHub 读取这个仓库
… 尚未检查
有许可证
我们还没有从 GitHub 读取这个仓库
✓ 通过
端点有响应
在 447 毫秒内响应（HTTP 200）
– 不适用
使用 OAuth 登录
无需登录
✓ 通过
工具描述中没有隐藏指令
已读取 11 个工具描述，未发现针对 AI 的隐藏指令

与“其他”中的其他服务器比较i

星标数多于此分类中其他 32712 个服务器的 0%
发布到注册中心的时间比此分类中其他 32712 个服务器的 95% 更新
基础检查结果等于或优于此分类中其他 32712 个服务器的 100%

与注册中心里这个分类中所有活跃的服务器比较。只有当发布者拥有该仓库时，星标数才计入。

常见问题

Folklore Clinical Variant Interpretation MCP 安全吗？

它在 3 项适用的基础检查中通过了 3 项。我们没有阅读代码。在添加密钥或令牌之前，请先看看这个服务器要求哪些权限，并使用只具备所需权限的密钥。

它需要哪些密钥或代码？

注册中心没有列出必需的密钥，不过有些服务器会在首次使用时要求你登录。

它在我的电脑上运行还是在云端？

它在作者的云端运行。通过互联网连接，无需安装，但你发送的内容会经过作者的服务器。

它还在维护吗？

GitHub 仓库最后更新于–，最新版本（2.0.0）于昨天进入注册中心。

哪些应用可以使用它？

支持 MCP 的应用，例如 Claude Desktop、Claude Code、Cursor 和 VS Code。它通过 URL 连接，所以接受远程 MCP 服务器的应用也可以使用，例如开启开发者模式的 ChatGPT。

有什么可以替代它？

同一分类中有：Spec Driven Development, Remote Desktop Commander, Aiterm MCP

替代选择

同一分类中其他作者的服务器，按星标数排序。

如何看卡片：★ GitHub 星标i三大支柱：评价 · 检查 · 使用情况i更新 = 最新版本发布到注册中心的时间i

Spec Driven Development

作者：formulahendry

MCP Server that facilitates spec-driven development workflows, not just Vibe Coding.

在你的电脑上运行★ 440MIT14个月前更新

安装

Remote Desktop Commander

作者：desktop-commander

Remote Desktop Commander: use files, terminal and processes on your own computers from any AI app.

在云端运行★ 211前天更新

安装

Aiterm MCP

作者：kitepon

Persistent terminals and one launcher for Claude, Codex, Grok, Cursor, and Antigravity harnesses.

在你的电脑上运行今天更新

安装

作者的 README

打开 README

按原文从作者的仓库复制。PopNx MCP 没有审查或背书其内容。HTML、图片和脚本已被移除。链接会离开本站。

Folklore Clinical Variant Interpretation MCP

One hosted MCP server for public scientific queries and authenticated case workflows.

Endpoint: https://api.helena.bio/folklore/v1/mcp

Version 2.0.0

Connect your MCP client directly to this Streamable HTTP endpoint. No local Folklore server is required. Anonymous callers receive 11 public tools. Send your Folklore API key in the Authorization Bearer header to access 18 additional case, source and result tools at the same endpoint. Invalid supplied credentials fail authentication; they do not select the anonymous catalog.

Create a key in your Folklore account for the selected account and sources. Keep it in your client's secret store, never in prompts, tool arguments or URLs. The selected account's native subscription capabilities, usage limits and eligible credits govern processing. A key does not grant funded compute.

See case workflows, the 18 authenticated tool schemas and the public task recipes.

Classify a variant

Connect your MCP client to:

https://api.helena.bio/folklore/v1/mcp

Access is anonymous. Call classify_germline_variant:

{"name":"classify_germline_variant","arguments":{"assembly":"GRCh38","query":"NM_007294.4:c.68_69del"}}

Input: one public GRCh38 nuclear germline SNV or simple indel smaller than 50 bp. Accepted notation includes supported HGVS, SPDI, rsID and genomic coordinates. Preserve transcript versions and reference alleles.

A resolved identity with successful interpretation includes automated ACMG/AMP classification, reported criteria, annotations, source evidence and provenance. Submitted ClinVar assertions retain their own source attribution alongside the Folklore classification. A VUS is a classification outcome.

Status	Next step
`resolved`	Read interpretation status, then classification and evidence.
`ambiguous`	Present candidates for an explicit allele choice.
`not_found`	Report the source-scoped miss.
`invalid_request`	Supply a corrected supported expression.
`unsupported`	Select a workflow for the requested variant type or assembly.
`resolution_unavailable`	Inspect the typed error and retry policy.

Interpretation status is success or unavailable. Transport, JSON-RPC, MCP and adapter errors have separate fields. See typed outcomes.

Scientific tools

Tool	Operation
`classify_germline_variant`	Resolve, classify and assess one supported germline variant.
`search_variant_literature`	Retrieve publications linked to a resolved variant.
`get_publication_details`	Retrieve the bibliographic record and abstract for a PMID.
`search_literature_corpus`	Search publications by scientific question or public identifier.
`get_gene_disease_associations`	Retrieve ClinGen assertions for an exact gene symbol or HGNC identifier.
`search_disease_genes`	Retrieve ClinGen assertions by MONDO identifier or disease-name substring.
`resolve_gene`	Resolve a human gene symbol, alias or stable identifier.
`get_gene_profile`	Read the selected HGNC gene at its returned snapshot.
`get_gene_section`	Continue one profile section using its cursor.
`search_gene_literature`	Retrieve a separate live publication capture for the selected gene.

ClinGen results preserve assertion-level disease identity, inheritance, validity assessment, panel, date and source links. Profile sections retain provider, assembly, release, units and pagination. Gene literature has its own capture identity. Follow gene-disease and gene-profile contracts for exact inputs.

support_helena provides links to the separate Helena Good service when the user asks about supporting Helena. An optional MCP App renders variant results.

Connect an agent or application

The hosted server uses stateless Streamable HTTP and MCP 2026-07-28. Requests carry matching protocol metadata and routing headers. Supported methods include server/discover, tools/list, tools/call, prompts/list, prompts/get, resources/list and resources/read.

Direct Streamable HTTP
OpenAI Agents SDK
Biomni
Biorouter
Dify, n8n, Galaxy, KNIME
Notebook workflow

The compatibility guide records protocol/client observations. All clients sharing egress use the same rate budget.

Agent Skill and workflow prompts

Install the portable Agent Skill using the installation guide. It routes pathogenicity, VUS, ClinVar, population-frequency, gene-disease and literature tasks to the hosted tools. The skill source includes OpenAI interface metadata.

Workflow prompts compose tool operations for classification, VUS assessment, ACMG/AMP explanation, identity verification and variant-literature comparison. Each accepts one public variant expression.

Run the adapter

The Apache-2.0 adapter implements MCP transport, public API clients and validated response projection. Folklore's scientific authorities produce normalization, annotation, evidence aggregation and classification.

python3.12 -m venv .venv

. .venv/bin/activate pip install -e '.[dev]' FOLKLORE_MCP_ENABLED=true \ FOLKLORE_LITERATURE_ENABLED=true \ FOLKLORE_GENE_DISEASE_ENABLED=true \ FOLKLORE_PUBLIC_GENE_ENABLED=true \ folklore-mcp

Capabilities are enabled through the flags above. Gene literature requires both public-gene and literature capabilities. The default upstream is https://api.helena.bio; local contract tests support localhost and 127.0.0.1. The standalone HTTP image uses Dockerfile.adapter; Dockerfile provides the pinned stdio bridge.

Verify and measure

pytest

ruff check . ruff format --check . python3 ops/reconcile_discovery.py

The read-only reconciler compares runtime, Server Card and Official Registry state, with separate aggregator observations. python3 ops/public_smoke.py checks discovery, prompts and resources.

Public measurement sources: variant interpretation, 100-case agent discovery, 60-query search discovery and genomic discovery cohort.

Registry and citation

Registry name: io.github.helena-bioinformatics/folklore
Publisher: Helena Bioinformatics
Website: https://folklore.helena.bio
Task routing metadata
Per-tool task contracts
Security reporting
Source boundary
Citation metadata

The immutable MCP adapter 1.6.0 archive is 10.5281/zenodo.23817704, from signed tag folklore-mcp-v1.6.0 at 55a332c6dd6bd4650e921c12ac145b8e0f90476a. The Biorouter-tag archive is 10.5281/zenodo.23818207.

License

Apache License 2.0. See LICENSE and NOTICE.

Automated variant classifications support qualified professional review and are not patient diagnoses or treatment recommendations.

Folklore Clinical Variant Interpretation MCP

概览

PopNx MCP 的三大支柱

它能帮你做什么

安装

安装之前

它能做什么

基础检查i

作者与仓库一致

仍在维护

有许可证

端点有响应

使用 OAuth 登录

工具描述中没有隐藏指令

与“其他”中的其他服务器比较i

常见问题

替代选择

Spec Driven Development

Remote Desktop Commander

Aiterm MCP

作者的 README

Folklore Clinical Variant Interpretation MCP

Classify a variant

Scientific tools

Connect an agent or application

Agent Skill and workflow prompts

Run the adapter

Verify and measure

Registry and citation

License